Background：The pyruvate dehydrogenase （PDH） complex is a nuclear-encoded mitochondrial multienzyme complex that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO（2）, and provides the primary link between glycolysis and the tricarboxylic acid （TCA） cycle. The PDH complex is composed of multiple copies of three enzymatic components： pyruvate dehydrogenase （E1）, dihydrolipoamide acetyltransferase （E2） and lipoamide dehydrogenase （E3）. The E1 enzyme is a heterotetramer of two alpha and two beta subunits. This gene encodes the E1 alpha 1 subunit containing the E1 active site, and plays a key role in the function of the PDH complex. Mutations in this gene are associated with pyruvate dehydrogenase E1-alpha deficiency and X-linked Leigh syndrome. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
仕様
Synonyms：ODPA,PDH,PDHA,PDHA1,PDHCE1A,PDHE1 A type I,PDHE1-A type I,PHE1A,Pyruvate Dehydrogenase （lipoamide） alpha 1,Pyruvate dehydrogenase complex,E1 alpha polypeptide 1,Pyruvate Dehydrogenase E1 alpha,Pyruvate dehydrogenase E1 component subunit alpha,somatic form,mitochondrial
Host：Rabbit
Reactivity：Human,Mouse,Rat
Applications：WB,IHC-p,ELISA
Concentration：1mg/mL
Immunogen：Synthesized peptide derived from the C-terminal region of human PDHA1
Purification Method：Affinity purification
Clonality：Polyclonal
Conjugation：Unconjugated
Buffer：PBS with 0.02％ sodium azide, 0.5％ BSA and 50％ glycerol, pH7.4
