Background：Responds to activation by environmental stress, pro-inflammatory cytokines and lipopolysaccharide （LPS） by phosphorylating a number of transcription factors, such as ELK1 and ATF2 and several downstream kinases, such as MAPKAPK2 and MAPKAPK5. Plays a critical role in the production of some cytokines, for example IL-6. May play a role in stabilization of EPO mRNA during hypoxic stress. Isoform Mxi2 activation is stimulated by mitogens and oxidative stress and only poorly phosphorylates ELK1 and ATF2. Isoform Exip may play a role in the early onset of apoptosis.
仕様
Synonyms：CSAID Binding Protein 1,CSAID binding protein,CSAID-binding protein,Csaids binding protein,CSBP 1,CSBP 2,CSBP,CSBP1,CSBP2,CSPB1,Cytokine suppressive anti-inflammatory drug-binding protein,EXIP,MAP kinase 14,MAP kinase MXI2,MAP kinase p38 alpha,MAPK 14,MAPK14,MAX interacting protein 2,MAX-interacting protein 2,Mitogen Activated Protein Kinase 14,Mitogen activated protein kinase p38 alpha,Mitogen-activated protein kinase 14,Mitogen-activated protein kinase p38 alpha,MK14,Mxi 2,MXI2,p38 ALPHA,p38,p38 MAP kinase,p38 MAPK,p38 mitogen activated protein kinase,p38ALPHA,p38alpha Exip,PRKM14,PRKM15,RK,SAPK2A
Host：Rabbit
Reactivity：Human,Mouse,Rat
Applications：WB,IHC-p,ELISA
Concentration：1mg/mL
Immunogen：Synthesized peptide derived from human p38 around the non-phosphorylation site of Thr180/Tyr182.
Purification Method：Affinity purification
Clonality：Polyclonal
Conjugation：Unconjugated
Buffer：PBS with 0.02％ sodium azide, 0.5％ BSA and 50％ glycerol, pH7.4
