Background：The protein encoded by this gene is a member of the TNF-receptor superfamily. This protein is an osteoblast-secreted decoy receptor that functions as a negative regulator of bone resorption. This protein specifically binds to its ligand, osteoprotegerin ligand, both of which are key extracellular regulators of osteoclast development. Studies of the mouse counterpart also suggest that this protein and its ligand play a role in lymph-node organogenesis and vascular calcification. Alternatively spliced transcript variants of this gene have been reported, but their full length nature has not been determined.
仕様
Synonyms：MGC29565,OCIF,OPG,Osteoclastogenesis inhibitory factor,Osteoprotegerin,PDB5,TNF receptor superfamily member 11b,TNFRSF 11B,TNFRSF11B,TR 1,TR1,TR11B,Tumor necrosis factor receptor superfamily member 11B
Host：Rabbit
Reactivity：Human,Mouse
Applications：WB,IHC-p,IF,ELISA
Concentration：1mg/mL
Immunogen：Synthesized peptide derived from the N-terminal region of human OPG
Purification Method：Affinity purification
Clonality：Polyclonal
Conjugation：Unconjugated
Buffer：PBS with 0.02％ sodium azide, 0.5％ BSA and 50％ glycerol, pH7.4
Dilution：WB 1：500-1：2000, IHC 1：100-1：300, IF 1：200-1：1000, ELISA 1：10000
Gene_ID（human）：4982
Swissprot：O00300
Isotype：IgG
Research Areas：Cancer, Cardiovascular, Metabolism, Immunology, Signal transduction
