Background：NFkB is a pleiotropic transcription factor which is present in almost all cell types and is involved in many biological processed such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. Activated NFkB translocates into the nucleus and stimulates the expression of genes involved in a wide variety of biological functions. Inappropriate activation of NFkB has been associated with a number of inflammatory diseases while persistent inhibition of NFkB leads to inappropriate immune cell development or delayed cell growth. NFKB1 appears to have dual functions such as cytoplasmic retention of attached NF-kappa-B proteins by p105 and generation of p50 by a cotranslational processing. This antibody can bind both p105 and p50 isoforms of NFKB1.
仕様
Synonyms：DKFZp686C01211,DNA binding factor KBF1,DNA binding factor KBF1 EBP1,DNA-binding factor KBF1,EBP 1,EBP-1,EBP1,KBF1,MGC54151,nf b,NF kappa B,NF kappaB,NF kappabeta,NF kB1,NFkappaB,NFKB 1,NFKB p105,NFKB p50,Nfkb1,NFKB1,Nuclear factor kappa B DNA binding subunit,Nuclear factor kappa-B,subunit 1,Nuclear factor NF kappa B p105 subunit,Nuclear factor NF kappa B p50 subunit,Nuclear factor NF-kappa-B p50 subunit,Nuclear factor of kappa light chain gene enhancer in B cells 1,Nuclear factor of kappa light polypeptide gene enhancer in B cells 1,Nuclear factor of kappa light polypeptide gene enhancer in B-cells 1,p105,p50,p84/NF-kappa-B1 p98,Transcription factor NFKB1
Host：Rabbit
Reactivity：Human,Mouse
Applications：WB,IHC-p,IF,ELISA
Concentration：1mg/mL
Immunogen：Synthesized peptide derived from human NFkappaB-p105/p50 around the non-phosphorylation site of Ser337.
Purification Method：Affinity purification
Clonality：Polyclonal
Conjugation：Unconjugated
Buffer：PBS with 0.02％ sodium azide, 0.5％ BSA and 50％ glycerol, pH7.4
Dilution：WB 1：500-1：2000, IHC 1：100-1：300, IF 1：200-1：1000, ELISA 1：40000
Gene_ID（human）：4790
Swissprot：P19838
Isotype：IgG
Research Areas：Cancer, Cell Biology, Epigenetics and Nuclear Signaling, Immunology, Signal transduction
