Background：This gene was identified as a locus frequently mutated in hereditary nonpolyposis colon cancer （HNPCC）. It is a human homolog of the E. coli DNA mismatch repair gene mutL, consistent with the characteristic alterations in microsatellite sequences （RER+phenotype） found in HNPCC. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Additional transcript variants have been described, but their full-length natures have not been determined.
仕様
Synonyms：COCA 2,COCA2,DNA mismatch repair protein Mlh1,FCC 2,FCC2,hMLH 1,hMLH1,HNPCC 2,HNPCC,HNPCC2,MGC5172,MLH 1,MLH1,MLH1,MutL homolog 1 （E. coli）,MutL homolog 1,MutL homolog 1 colon cancer nonpolyposis type 2,MutL homolog 1,colon cancer,nonpolyposis type 2 （E. coli）,MutL protein homolog 1,MutL,E. coli,homolog of,1
Host：Rabbit
Reactivity：Human,Mouse,Rat
Applications：WB,IF,ELISA
Concentration：1mg/mL
Immunogen：Synthesized peptide derived from the Internal region of human MLH1
Purification Method：Affinity purification
Clonality：Polyclonal
Conjugation：Unconjugated
Buffer：PBS with 0.02％ sodium azide, 0.5％ BSA and 50％ glycerol, pH7.4
Dilution：WB 1：500-1：2000, IF 1：100-1：300, ELISA 1：20000
Gene_ID（human）：4292
Swissprot：P40692
Isotype：IgG
Research Areas：Cancer, Epigenetics and Nuclear Signaling
