Background：This gene encodes a nuclear-localized E3 ubiquitin ligase. The encoded protein can promote tumor formation by targeting tumor suppressor proteins, such as p53, for proteasomal degradation. This gene is itself transcriptionally-regulated by p53. Overexpression or amplification of this locus is detected in a variety of different cancers. There is a pseudogene for this gene on chromosome 2. Alternative splicing results in a multitude of transcript variants, many of which may be expressed only in tumor cells.
仕様
Synonyms：ACTFS,Double minute 2 protein,E3 ubiquitin-protein ligase Mdm2,Hdm 2,Hdm2,HDMX,MDM 2,MDM2,MDM2 oncogene E3 ubiquitin protein ligase,Mdm2 p53 E3 ubiquitin protein ligase homolog,Mdm2 transformed 3T3 cell double minute 2 p53 binding protein （mouse） binding protein 104kDa,MDM2,MDM2BP,Mouse Double Minute 2,MTBP,Murine Double Minute Chromosome 2,Oncoprotein Mdm2,p53 Binding Protein Mdm2,p53-binding protein Mdm2,Ubiquitin protein ligase E3 Mdm2,Ubiquitin protein ligase E3 Mdm2
Host：Rabbit
Reactivity：Human,Mouse,Monkey
Applications：WB,IHC-p,IF,ELISA
Concentration：1mg/mL
Immunogen：Synthesized peptide derived from human MDM2 around the non-phosphorylation site of Ser166.
Purification Method：Affinity purification
Clonality：Polyclonal
Conjugation：Unconjugated
Buffer：PBS with 0.02％ sodium azide, 0.5％ BSA and 50％ glycerol, pH7.4
Dilution：WB 1：500-1：2000, IHC 1：100-1：300, IF 1：200-1：1000, ELISA 1：5000
Gene_ID（human）：4193
Swissprot：Q00987
Isotype：IgG
Research Areas：Cancer, Cell Biology, Epigenetics and Nuclear Signaling
