Background：Acts as part of the IKK complex in the conventional pathway of NF-kappa-B activation and phosphorylates inhibitors of NF-kappa-B thus leading to the dissociation of the inhibitor/NF-kappa-B complex and ultimately the degradation of the inhibitor. As part of the non-canonical pathway of NF-kappa-B activation, the MAP3K14-activated CHUK/IKKA homodimer phosphorylates NFKB2/p100 associated with RelB, inducing its proteolytic processing to NFKB2/p52 and the formation of NF-kappa-B RelB-p52 complexes. Also phosphorylates NCOA3. Phosphorylates 'Ser-10' of histone H3 at NF-kappa-B-regulated promoters during inflammatory responses triggered by cytokines.
仕様
Synonyms：chuk,CHUK1,Conserved Helix Loop Helix Ubiquitous Kinase,Conserved helix loop ubiquitous kinase,Conserved helix-loop-helix ubiquitous kinase,I Kappa B Kinase 1,I Kappa B Kinase Alpha,I-kappa-B kinase 1,I-kappa-B kinase alpha,IkappaB kinase,IkB kinase alpha subunit,IkBKA,IKK 1,IKK A,IKK a kinase,IKK-A,IKK-alpha,IKK1,IKKA,IKKA,Inhibitor Of Kappa Light Polypeptide Gene Enhancer In B Cells,Inhibitor Of Nuclear Factor Kappa B Kinase Alpha Subunit,Inhibitor of nuclear factor kappa-B kinase subunit alpha,NFKBIKA,Nuclear Factor Kappa B Inhibitor Kinase Alpha,Nuclear factor NF kappa B inhibitor kinase alpha,Nuclear factor NF-kappa-B inhibitor kinase alpha,Nuclear factor NFkappaB inhibitor kinase alpha,Nuclear Factor Of Kappa Light Chain Gene Enhancer In B Cells Inhibitor,TCF-16,TCF16,Transcription factor 16
Host：Rabbit
Reactivity：Human,Mouse,Rat
Applications：WB,IHC-p,ELISA
Concentration：1mg/mL
Immunogen：Synthesized peptide derived from human IKKa around the non-phosphorylation site of Thr23.
Purification Method：Affinity purification
Clonality：Polyclonal
Conjugation：Unconjugated
Buffer：PBS with 0.02％ sodium azide, 0.5％ BSA and 50％ glycerol, pH7.4
