Background：High mobility group （HMG） proteins 1 and 2 are ubiquitous non-histone components of chromatin. Evidence suggests that the binding of HMG proteins to DNA induces alterations in the DNA architecture including DNA bending and unwinding of the helix. HMG proteins synergize with Oct-2,members of the NFkappaB family, ATF-2 and c-Jun to activate transcription.Other studies indicate that phosphorylation of HMG protein is required to stimulate the transcriptional activity of the protein. Human HMG-1 and HMG-2 both contain two DNA-binding domains, termed HMG boxes. HMG proteins bind single-stranded DNA but induce conformational changes in double-stranded DNA alone.
仕様
Synonyms：Amphoterin,Chromosomal protein,nonhistone,HMG1,DKFZp686A04236,High mobility group 1,High mobility group box 1,High mobility group protein 1,High mobility group protein B1,high-mobility group （nonhistone chromosomal） protein 1,HMG-1,HMG1,HMG3,HMGB 1,HMGB1,HMGB1,NONHISTONE CHROMOSOMAL PROTEIN HMG1,SBP 1,Sulfoglucuronyl carbohydrate binding protein
Host：Rabbit
Reactivity：Human,Mouse,Rat
Applications：WB,IHC-p,IF,ELISA
Concentration：1mg/mL
Immunogen：Synthesized peptide derived from the Internal region of human HMG-1
Purification Method：Affinity purification
Clonality：Polyclonal
Conjugation：Unconjugated
Buffer：PBS with 0.02％ sodium azide, 0.5％ BSA and 50％ glycerol, pH7.4
Dilution：WB 1：500-1：2000, IHC 1：100-1：300, IF 1：200-1：1000, ELISA 1：20000
Gene_ID（human）：3146
Swissprot：P09429
Isotype：IgG
Research Areas：Cancer, Epigenetics and Nuclear Signaling
