Background：Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Required for checkpoint-mediated arrest of cell cycle progression in response to low doses of ionizing radiation and for efficient repair of DNA double strand breaks （DSBs） specifically when modified by C-terminal phosphorylation.
仕様
Synonyms：H2A histone family member X,H2A histone family member X,H2A.FX,H2A.X,H2a/x,H2AFX,H2AX,H2AX,Histone H2A.X
Host：Rabbit
Reactivity：Human,Mouse,Rat
Applications：WB,IHC-p,IF,ELISA
Concentration：1mg/mL
Immunogen：Synthesized peptide derived from human Histone H2A.X around the non-phosphorylation site of Ser139.
Purification Method：Affinity purification
Clonality：Polyclonal
Conjugation：Unconjugated
Buffer：PBS with 0.02％ sodium azide, 0.5％ BSA and 50％ glycerol, pH7.4
Dilution：WB 1：500-1：2000, IHC 1：100-1：300, IF 1：200-1：1000, ELISA 1：10000
Gene_ID（human）：3014
Swissprot：P16104
Isotype：IgG
Research Areas：Cancer, Epigenetics and Nuclear Signaling
