Background：Functions as a master transcriptional regulator of the adaptive response to hypoxia. Under hypoxic conditions activates the transcription of over 40 genes, including, erythropoietin, glucose transporters, glycolytic enzymes, vascular endothelial growth factor, and other genes whose protein products increase oxygen delivery or facilitate metabolic adaptation to hypoxia. Plays an essential role in embryonic vascularization, tumor angiogenesis and pathophysiology of ischemic disease. Binds to core DNA sequence 5'-[AG]CGTG-3' within the hypoxia response element （HRE） of target gene promoters. Activation requires recruitment of transcriptional coactivators such as CREBPB and EP300. Activity is enhanced by interaction with both, NCOA1 or NCOA2. Interaction with redox regulatory protein APEX seems to activate CTAD and potentiates activation by NCOA1 and CREBBP.
仕様
Synonyms：ARNT interacting protein,ARNT-interacting protein,Basic helix loop helix PAS protein MOP1,Basic-helix-loop-helix-PAS protein MOP1,bHLHe78,Class E basic helix-loop-helix protein 78,HIF 1A,HIF 1alpha,HIF-1-alpha,HIF1 A,HIF1 Alpha,HIF1,HIF1-alpha,HIF1A,HIF1A,Hypoxia inducible factor 1 alpha,Hypoxia inducible factor 1 alpha isoform I.3,Hypoxia inducible factor 1 alpha subunit,Hypoxia inducible factor 1 alpha subunit basic helix loop helix transcription factor,Hypoxia inducible factor 1,alpha subunit （basic helix loop helix transcription factor）,Hypoxia inducible factor1alpha,Hypoxia-inducible factor 1-alpha,Member of PAS protein 1,Member of PAS superfamily 1,Member of the PAS Superfamily 1,MOP 1,MOP1,PAS domain-containing protein 8,PASD 8,PASD8
Host：Rabbit
Reactivity：Human,Mouse,Rat
Applications：WB,IHC-p,IF,ELISA
Concentration：1mg/mL
Immunogen：Synthesized peptide derived from the Internal region of human HIF-1a.
Purification Method：Affinity purification
Clonality：Polyclonal
Conjugation：Unconjugated
Buffer：PBS with 0.02％ sodium azide, 0.5％ BSA and 50％ glycerol, pH7.4
Dilution：WB 1：500-1：2000, IHC 1：100-1：300, IF 1：50-1：200, ELISA 1：40000
Gene_ID（human）：3091
Swissprot：Q16665
Isotype：IgG
Research Areas：Cancer, Cardiovascular, Epigenetics and Nuclear Signaling, Metabolism
