Background：HES6 is a transcription cofactor that iteself does not bind to DNA but suppresses both HES1-mediated N box-dependent transcriptional repression and binding of HES1 to E box sequences. It also suppresses HES1-mediated inhibition of the heterodimer formed by ASCL1/MASH1 and TCFEA2/E47, allowing ASCL1 and TCFEA2 to upregulate transcription in its presence. HES6 appears to have novel functions in tumour and cancer cell lines, although these have not yet been elucidated fully.
仕様
Synonyms：bHLHb41,bHLHc23,C HAIRY1,Class B basic helix-loop-helix protein 41,Hairy and enhancer of split 6,Hairy/enhancer of split 6,Drosophila,homolog of,6,HES 6,hes family bHLH transcription factor 6,Transcription cofactor HES6
Host：Rabbit
Reactivity：Human
Applications：WB,IHC-p,ELISA
Concentration：1mg/mL
Immunogen：Synthesized peptide derived from the N-terminal region of human HES-6
Purification Method：Affinity purification
Clonality：Polyclonal
Conjugation：Unconjugated
Buffer：PBS with 0.02％ sodium azide, 0.5％ BSA and 50％ glycerol, pH7.4
