Background：Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones （H2A, H2B, H3 and H4）. Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Involved in muscle maturation by repressing transcription of myocyte enhancer MEF2C. During muscle differentiation, it shuttles into the cytoplasm, allowing the expression of myocyte enhancer factors.
仕様
Synonyms：Antigen NY CO 9,Antigen NY-CO-9,HD5,HDAC 5,HDAC5,HDAC5,Histone deacetylase 5,NY CO 9
Host：Rabbit
Reactivity：Human,Mouse
Applications：WB,IHC-p,IF,ELISA
Concentration：1mg/mL
Immunogen：Synthesized peptide derived from human HDAC5 around the non-phosphorylation site of Ser498.
Purification Method：Affinity purification
Clonality：Polyclonal
Conjugation：Unconjugated
Buffer：PBS with 0.02％ sodium azide, 0.5％ BSA and 50％ glycerol, pH7.4
Dilution：WB 1：500-1：2000, IHC 1：100-1：300, IF 1：200-1：1000, ELISA 1：20000
Gene_ID（human）：10014
Swissprot：Q9UQL6
Isotype：IgG
Research Areas：Cancer, Cardiovascular, Epigenetics and Nuclear Signaling, Stem cells
