Background：Transcription factor involved in the regulation of the insulin signaling pathway. Binds to insulin-response elements （IREs） and can activate transcription of IGFBP1. Down-regulates expression of HIF1A and suppresses hypoxia-induced transcriptional activation of HIF1A-modulated genes. Also involved in negative regulation of the cell cycle.
仕様
Synonyms：AFX,AFX1,Afxh,ALL1-fused gene from X chromosome,Fork head domain transcription factor AFX1,Forkhead box O4,Forkhead box protein O4,FOXO 4,Foxo4,FOXO4,MGC117660,MGC120490,Mixed lineage leukemia,translocated to,7,MLLT7,Myeloid/lymphoid or mixed lineage leukemia （trithorax homolog,Drosophila）,translocated to,7,Myeloid/lymphoid or mixed lineage leukemia,translocated to,7,RGD1561201
Host：Rabbit
Reactivity：Human,Mouse,Monkey
Applications：WB,IF,ELISA
Concentration：1mg/mL
Immunogen：Synthesized peptide derived from human FoxO4 around the non-phosphorylation site of Thr451.
Purification Method：Affinity purification
Clonality：Polyclonal
Conjugation：Unconjugated
Buffer：PBS with 0.02％ sodium azide, 0.5％ BSA and 50％ glycerol, pH7.4
Dilution：WB 1：500-1：2000, IF 1：100-1：300, ELISA 1：20000
Gene_ID（human）：4303
Swissprot：P98177
Isotype：IgG
Research Areas：Cancer, Epigenetics and Nuclear Signaling
