Background：Bone morphogenetic proteins （BMPs） were first identified as molecules that can induce ectopic bone and cartilage formation （1,2）. BMPs belongs to the TGF-b superfamily, playing many diverse functions during development （3）. BMPs are synthesized as precursor proteins and then processed by cleavage to release the c-terminal mature BMP. BMPs initiate signaling by binding to a receptor complex containing type I and type II serine/threonine receptor kinases that then phosphorylate Smad （mainly Smad1, 5 and 8）, resulting the translocation of Smad into the nucleus. BMP was also reported to activate MAPK pathways in some systems （3,4）.BMP7, also known as osteogenic protein-1 （OP-1）, is found to be upregulated in some cancer cells （5-7）, and may play a role in cancer metastasis （7-9）.
仕様
Synonyms：BMP 7,BMP-7,Bmp7,BMP7,Bone morphogenetic protein 7,Bone morphogenic protein 7,Eptotermin alfa,OP 1,OP-1,OP1,Osteogenic protein 1
Host：Rabbit
Reactivity：Human,Mouse,Rat
Applications：WB,IHC-p,ELISA
Concentration：1mg/mL
Immunogen：Synthesized peptide derived from the Internal region of human BMP-7.
Purification Method：Affinity purification
Clonality：Polyclonal
Conjugation：Unconjugated
Buffer：PBS with 0.02％ sodium azide, 0.5％ BSA and 50％ glycerol, pH7.4
