Background：May be directly involved in regulating the cleavage of polar spindle microtubules and is a key regulator for the onset of cytokinesis during mitosis. Component of the chromosomal passenger complex （CPC）, a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Phosphorylates 'Ser-10' and 'Ser-28' of histone H3 during mitosis. Required for kinetochore localization of BUB1 and SGOL1. Interacts with INCENP.
仕様
Synonyms：AIK2,AIM-1,AIM1,ARK-2,ARK2,AurB,AURKB,AURKB,Aurora 1,Aurora and Ipl1 like midbody associated protein 1,Aurora kinase B,Aurora related kinase 2,Aurora- and Ipl1-like midbody-associated protein 1,Aurora-B,Aurora-related kinase 2,Aurora/IPL1 related kinase 2,Aurora/IPL1-related kinase 2,IPL1,PPP1R48,Protein phosphatase 1 regulatory subunit 48,Serine/theronine kinase 12,Serine/threonine protein kinase 12,Serine/threonine-protein kinase 12,Serine/threonine-protein kinase aurora-B,STK-1,STK1,STK12,STK5
Host：Rabbit
Reactivity：Human,Mouse,Rat
Applications：WB,IHC-p,IF,ELISA
Concentration：1mg/mL
Immunogen：Synthesized peptide derived from human ARK-2 around the non-phosphorylation site of Tyr12.
Purification Method：Affinity purification
Clonality：Polyclonal
Conjugation：Unconjugated
Buffer：PBS with 0.02％ sodium azide, 0.5％ BSA and 50％ glycerol, pH7.4
Dilution：WB 1：500-1：2000, IHC 1：100-1：300, IF 1：200-1：1000, ELISA 1：40000
Gene_ID（human）：9212
Swissprot：Q96GD4
Isotype：IgG
Research Areas：Cancer, Cell Biology, Epigenetics and Nuclear Signaling, Signal transduction
