Background：The A-kinase anchor proteins （AKAPs） are a group of structurally diverse proteins, which have the common function of binding to the regulatory subunit of protein kinase A （PKA） and confining the holoenzyme to discrete locations within the cell. This gene encodes a member of the AKAP family. The encoded protein binds to the RII-beta regulatory subunit of PKA, and also to protein kinase C and the phosphatase calcineurin. It is predominantly expressed in cerebral cortex and may anchor the PKA protein at postsynaptic densities （PSD） and be involved in the regulation of postsynaptic events. It is also expressed in T lymphocytes and may function to inhibit interleukin-2 transcription by disrupting calcineurin-dependent dephosphorylation of NFAT.
仕様
Synonyms：A kinase （PRKA） anchor protein 5,A kinase anchor protein 5,A kinase anchor protein 79kDa,A kinase anchoring protein 75/79,A-kinase anchor protein 5,A-kinase anchor protein 79 kDa,AKAP 5,AKAP 75,AKAP 79,AKAP-5,Akap5,AKAP5,AKAP75,AKAP79,cAMP dependent protein kinase regulatory subunit II high affinity binding protein,cAMP-dependent protein kinase regulatory subunit II high affinity-binding protein,H21
Host：Rabbit
Reactivity：Human
Applications：WB,IHC-p,IF,ELISA
Concentration：1mg/mL
Immunogen：Synthesized peptide derived from the N-terminal region of human AKAP 79
Purification Method：Affinity purification
Clonality：Polyclonal
Conjugation：Unconjugated
Buffer：PBS with 0.02％ sodium azide, 0.5％ BSA and 50％ glycerol, pH7.4
Dilution：WB 1：500-1：2000, IHC 1：100-1：300, IF 1：200-1：1000, ELISA 1：10000
