Background：PDCD1 （Programmed Cell Death 1） is a cell surface membrane protein of the immunoglobulin superfamily. It is expressed in pro-B-cells and is thought to play a role in their differentiation. In mice, expression of this gene is induced in the thymus when anti-CD3 antibodies are injected and large numbers of thymocytes undergo apoptosis. Mice deficient for this gene bred on a BALB/c background developed dilated cardiomyopathy and died from congestive heart failure. These studies suggest that this gene product may also be important in T cell function and contribute to the prevention of autoimmune diseases.Diseases associated with PDCD1 includeSystemic Lupus Erythematosus 2andMultiple Sclerosis, Disease Progression, Modifier Of. Among its related pathways areInnate Immune SystemandCD28 co-stimulation.
仕様
Synonyms：CD279,CD279 antigen,hPD 1,hPD l,hPD-1,hSLE1,PD 1,PD-1,PD1,PDCD 1,PDCD1,PDCD1,Programmed cell death 1,Programmed cell death 1 protein,Programmed cell death protein 1,Protein PD 1,Protein PD-1,SLEB2,Systemic lupus erythematosus susceptibility 2
Host：Mouse
Reactivity：Human
Applications：IHC-p
Concentration：1mg/mL
Immunogen：Full length protein from eukaryotic expression system.
Purification Method：Affinity purification
Clonality：Monoclonal
Clone No.：LEA13
Conjugation：Unconjugated
Buffer：PBS with 50％ glycerol, 0.5％ BSA and 0.02％ sodium azide.
