Background：NPM1 （Nucleophosmin） is a phosphoprotein which moves between the nucleus and the cytoplasm. It is thought to be involved in several processes including regulation of the ARF/p53 pathway. Mutations in this gene are associated with acute myeloid leukemia. More than a dozen pseudogenes of this gene have been identified. Alternative splicing results in multiple transcript variants. Diseases associated with NPM1 includeLeukemia, Acute MyeloidandLymphomatoid Papulosis. Among its related pathways areValidated targets of C-MYC transcriptional activationandChromosome Maintenance.
仕様
Synonyms：B23,MGC104254,NO38,NPM,NPM,NPM1,Nucleolar phosphoprotein B23,Nucleolar protein NO38,Nucleophosmin （nucleolar phosphoprotein B23 numatrin）,Nucleophosmin,nucleophosmin nucleoplasmin family member 1,Nucleophosmin/nucleoplasmin family member 1,Numatrin,OTTHUMP00000161024,OTTHUMP00000161025,OTTHUMP00000223397,OTTHUMP00000223398
Host：Mouse
Reactivity：Human
Applications：IHC-p
Concentration：1mg/mL
Immunogen：Full length protein from eukaryotic expression system.
Purification Method：Affinity purification
Clonality：Monoclonal
Clone No.：LE0201
Conjugation：Unconjugated
Buffer：PBS with 50％ glycerol, 0.5％ BSA and 0.02％ sodium azide.
Dilution：IHC 1：100-1：200
Swissprot：P06748
Isotype：IgG
Research Areas：Cancer, Epigenetics and Nuclear Signaling
