Background：N- cadherin is a Ca2+ dependent transmembrane glycoprotein with a molecular weight of 140 kDa, which can promote and protection the cell adhesion. It is reported that N- cadherin express in many tissues, such as neurons, endothelial cells, muscle cells and some early hematopoietic progenitor cells. N- cadherin may also express in tissues of non-epithelial malignant tumors, including malignant mesothelioma, synovial sarcoma, malignant melanoma, epithelioid sarcoma, epithelioid angiosarcoma and clear cell sarcoma. Ovarian serous tumors and endometrial cancer are positive expression of N-cadherin, while ovarian mucinous tumor is negative expression of N-cadherin. N-cadherin is also expressed in renal cell carcinoma, medullary carcinoma of breast and carcinoma sareomatodes. This antibody can be used as one of index for identification of celiothelioma and adenocarcinoma.
仕様
Synonyms：CADH2,Cadherin 2,Cadherin 2 N cadherin neuronal,Cadherin 2 type 1,Cadherin 2 type 1 N cadherin neuronal,Cadherin 2,type 1,N-cadherin （neuronal）,Cadherin-2,Cadherin2,Calcium dependent adhesion protein neuronal,CD325,CD325 antigen,CDH2,CDHN,CDw325,CDw325 antigen,N cadherin 1,N-cadherin,NCAD,Neural cadherin,OTTHUMP00000066304,OTTHUMP00000067378
Host：Mouse
Reactivity：Human
Applications：IHC-p
Concentration：1mg/mL
Immunogen：Full length protein from eukaryotic expression system.
Purification Method：Affinity purification
Clonality：Monoclonal
Clone No.：LE0199
Conjugation：Unconjugated
Buffer：PBS with 50％ glycerol, 0.5％ BSA and 0.02％ sodium azide.
Dilution：IHC 1：100-1：200
Swissprot：P19022
Isotype：IgG
Research Areas：Cancer, Signal transduction, Stem cells
