Background：p63 protein is a member of the p53 tumor suppressor family which also includes the p73 protein. These proteins act as transcription factors that regulate the progression of the cell through its cell cycle and cell death （apoptosis） in response to environmental stimuli, such as DNA damage and hypoxia. The p63 protein is expressed in the nucleus of basal cells in many types of epithelium. Antibodies to p63 protein may be useful as an aid in the differentiation between benign prostate lesions and prostate adenocarcinoma, between breast carcinoma in situ and breast carcinoma, between squamous cell carcinoma and adenocarcinoma of the lung and furthermore to differentiate uterine cervical squamous carcinoma from cervical adenocarcinoma.
仕様
Synonyms：AIS,Amplified in squamous cell carcinoma,B（p51A）,B（p51B）,Chronic ulcerative stomatitis protein,CUSP,DN p63 alpha 1,DNp63,EEC3,id：ibd3516,Keratinocyte transcription factor,Keratinocyte transcription factor KET,KET,LMS,MGC115972,MGC192897,NBP,OFC8,OTTHUMP00000209732,OTTHUMP00000209733,OTTHUMP00000209734,OTTHUMP00000209735,OTTHUMP00000209737,OTTHUMP00000209738,OTTHUMP00000209739,OTTHUMP00000209740,OTTHUMP00000209741,OTTHUMP00000209742,OTTHUMP00000209743,OTTHUMP00000209744,p40,p51,P51/P63,p53-related protein p63,p53CP,p63,P63,p73H,p73L,RHS,SHFM4,TAp63alpha,TP53CP,TP53L,TP63,TP73L,Transformation related protein 63,Transformation-related protein 63,Trp53rp1,Trp63,Tumor protein 63,Tumor protein p53-competing protein,Tumor protein p53-like,Tumor protein p63,Tumor protein p63 deltaN isoform delta,Tumor protein p73,Tumor protein p73-like
Host：Mouse
Reactivity：Human
Applications：IHC-p
Concentration：1mg/mL
Immunogen：Full length protein from eukaryotic expression system.
Purification Method：Affinity purification
Clonality：Monoclonal
Clone No.：LE0209
Conjugation：Unconjugated
Buffer：PBS with 50％ glycerol, 0.5％ BSA and 0.02％ sodium azide.
Dilution：IHC 1：100-1：200
Swissprot：Q9H3D4
Isotype：IgG
Research Areas：Cancer, Cell biology, Epigenetics and Nuclear Signaling
