Background：Sequestosome 1 （SQSTM1/p62） is a multifunctional adaptor protein implicated in selective autophagy,cell signaling pathways,and tumorigenesis. p62 has been implicated in shuttling ubiquitinated and sometimes aggregated proteins for autophagic degradation. As a autophagy-specific substrate,p62 is degraded during the autophagic process,which makes intracellular level of p62 as a marker for autophagy flux. p62 is at the cross-roads of several signaling pathways including Ras/ Raf/ MAPK and NFkappaB and plays important role in cancer. p62 is a component of inclusion bodies/ protein aggregates found in human diseases,including Huntington's disease,Alzheimer's disease,Parkinson's disease in the brain,and nephropathic cystinosis in kidney （22074114,22860231,22714671）. The molecular weight of p62 is predicted as 48/ 38 kDa,while western blot analyses using this antibody demonstrate the major band around 60-62 kDa in various tissues.
仕様
Synonyms：A170,DMRV,EBI 3 associated protein of 60 kDa,EBI 3 associated protein p60,EBI3 associated protein of 60 kDa,EBI3 associated protein p60,EBI3-associated protein of 60 kDa,EBIAP,FTDALS3,MGC127197,ORCA,OSF-6,Osi,OSIL,Oxidative stress induced like,p60,p62,p62B,Paget disease of bone 3,PDB 3,PDB3,Phosphotyrosine independent ligand for the Lck SH2 domain of 62 kDa,Phosphotyrosine independent ligand for the Lck SH2 domain p62,Phosphotyrosine-independent ligand for the Lck SH2 domain of 62 kDa,PKC-zeta-interacting protein,Protein kinase C-zeta-interacting protein,Sequestosome 1,Sequestosome-1,SQSTM 1,SQSTM,Sqstm1,STAP,STONE14,Ubiquitin binding protein p62,Ubiquitin-binding protein p62,ZIP 3,ZIP,ZIP3
Host：Rabbit
Reactivity：Human,Mouse,Rat
Applications：WB
Concentration：1.5 mg/mL
Immunogen：KLH conjugated Synthetic peptide corresponding to Human SQSTM1
Purification Method：Affinity purification
Clonality：Polyclonal
Conjugation：Unconjugated
Buffer：PBS with 0.02％ sodium azide,100 ug/ml BSA and 50％ glycerol.
Dilution：WB 1：500-1：1000
Swissprot：Q13501,Q64337,O08623
Isotype：IgG
Research Areas：Cancer, Cardiovascular, Epigenetics and Nuclear Signaling, Metabolism, Signal transduction
