Background：There are at least four distinct but related alkaline phosphatases： intestinal, placental, placental-like, and liver/bone/kidney （tissue non-specific）. The first three are located together on chromosome 2, while the tissue non-specific form is located on chromosome 1. The product of this gene is a membrane bound glycosylated enzyme that is not expressed in any particular tissue and is, therefore, referred to as the tissue-nonspecific form of the enzyme. The exact physiological function of the alkaline phosphatases is not known. A proposed function of this form of the enzyme is matrix mineralization; however, mice that lack a functional form of this enzyme show normal skeletal development. This enzyme has been linked directly to hypophosphatasia, a disorder that is characterized by hypercalcemia and includes skeletal defects. The character of this disorder can vary, however, depending on the specific mutation since this determines age of onset and severity of symptoms. Alternatively spliced transcript variants have been described.
仕様
Synonyms：AKP2,Alkaline phosphatase liver/bone/kidney,Alkaline phosphatase liver/bone/kidney isozyme,Alkaline phosphatase tissue nonspecific isozyme,Alkaline phosphatase,tissue-nonspecific isozyme,Alkaline phosphomonoesterase,Alpl,AP TNAP,AP-TNAP,APTNAP,BAP,FLJ40094,FLJ93059,Glycerophosphatase,HOPS,Liver/bone/kidney type alkaline phosphatase,MGC161443,MGC167935,PHOA,PPBT,Tissue non specific alkaline phosphatase,Tissue nonspecific ALP,TNAP,TNSALP
Host：Rabbit
Reactivity：Human,Mouse,Rat
Applications：WB
Concentration：200 ug/mL
Immunogen：Recombinant protein corresponding to Mouse Alkaline Phosphatase
Purification Method：Affinity purification
Clonality：Polyclonal
Conjugation：Unconjugated
Buffer：PBS with 0.02％ sodium azide,100 ug/ml BSA and 50％ glycerol.
Dilution：WB 1：500-1：1000
Swissprot：P05186,P09242,P08289
Isotype：IgG
Research Areas：Cancer, Cell Biology, Tags ＆ Cell Markers
