Background：JUN is also named as c-Jun and AP1,belongs to the bZIP family and Jun subfamily. JUN,the most extensively studied protein of the activator protein-1 （AP-1） complex,is involved in numerous cell activities,such as proliferation,apoptosis,survival,tumorigenesis and tissue morphogenesis. JUN is a transcription factor that recognizes and binds to the enhancer heptamer motif 5'-TGA[CG]TCA-3'. It promotes activity of NR5A1 when phosphorylated by HIPK3 leading to increased steroidogenic gene expression upon cAMP signaling pathway stimulation. JUN is a basic leucine zipper （bZIP） transcription factor that acts as homo- or heterodimer,binding to DNA and regulating gene transcription. In additon,extracellular signals can induce post-translational modifications of JUN,resulting in altered transcriptional activity and target gene expression. More over,it has uncovered multiple layers of a complex regulatory scheme in which JUN is able to crosstalk,amplify and integrate different signals for tissue development and disease. Jun is predominantly nuclear,ubiquitinated Jun colocalizes with lysosomal proteins.
仕様
Synonyms：Activator protein 1,AP 1,AP1,cJun,Enhancer Binding Protein AP1,Jun Activation Domain Binding Protein,JUN,Jun oncogene,JUN protein,Jun proto oncogene,JUN,JUNC,Oncogene JUN,p39,Proto oncogene c jun,Proto oncogene cJun,Proto-oncogene c-jun,Transcription Factor AP 1,Transcription factor AP-1,Transcription Factor AP1,V jun avian sarcoma virus 17 oncogene homolog,V jun sarcoma virus 17 oncogene homolog （avian）,V jun sarcoma virus 17 oncogene homolog,V-jun avian sarcoma virus 17 oncogene homolog,vJun Avian Sarcoma Virus 17 Oncogene Homolog
Host：Rabbit
Reactivity：Human,Mouse,Rat
Applications：IHC
Concentration：1.1 mg/mL
Immunogen：KLH conjugated Synthetic peptide corresponding to Human c-Jun.
Purification Method：Affinity purification
Clonality：Polyclonal
Conjugation：Unconjugated
Buffer：PBS with 0.02％ sodium azide,100 ug/ml BSA and 50％ glycerol.
Dilution：IHC 1：1000-1：2000
Swissprot：P05412,P05627,P17325
Isotype：IgG
Research Areas：Cancer, Epigenetics and Nuclear Signaling, Immunology, Signal transduction
