Background：SIRT1,also named as SIR2L1,contains a deacetylase sirtuin-type domain and belongs to the sirtuin family. It regulates processes such as apoptosis and muscle differentiation by deacetylating key proteins. SIRT1 in particular initiates several signaling events relevant to cardioprotection,including： activation of endothelial nitric oxide synthase,insulin receptor signaling,and autophagy. In addition SIRT1 activation elicits resistance to oxidative stress via regulation of transcription factors and co-activators such as FOXO,Hif-2a,and NF-kB. SIRT1 regulates the p53-dependent DNA damage response pathway by binding to and deacetylating p53,specifically at Lysine 382.
仕様
Synonyms：75SirT1,hSIR2,hSIRT1,HST2,S. cerevisiae,homolog of,NAD dependent deacetylase sirtuin 1,NAD dependent protein deacetylase sirtuin 1,OTTHUMP00000198111,OTTHUMP00000198112,Regulatory protein SIR2 homolog 1,SIR1,SIR2,SIR2 like 1,SIR2 like protein 1,SIR2,S.cerevisiae,homolog-like 1,SIR2-like protein 1,SIR2ALPHA,SIR2L1,Sirt1,SirtT1 75 kDa fragment,Sirtuin （silent mating type information regulation 2 homolog） 1 （S. cerevisiae）,Sirtuin 1,Sirtuin type 1
Host：Rabbit
Reactivity：Mouse
Applications：IHC
Concentration：1.2 mg/mL
Immunogen：Recombinant protein corresponding to Mouse SIRT1
Purification Method：Affinity purification
Clonality：Polyclonal
Conjugation：Unconjugated
Buffer：PBS with 0.02％ sodium azide,100 ug/ml BSA and 50％ glycerol.
Dilution：IHC 1：300-1：700
Swissprot：Q923E4
Isotype：IgG
Research Areas：Cancer, Cell Biology, Epigenetics and Nuclear Signaling, Metabolism, Microbiology, Tags ＆ Cell Markers
