Background：The protein encoded by this gene phosphorylates the alpha subunit of eukaryotic translation-initiation factor 2 （EIF2）, leading to its inactivation, and thus to a rapid reduction of translational initiation and repression of global protein synthesis. It is a type I membrane protein located in the endoplasmic reticulum （ER）, where it is induced by ER stress caused by malfolded proteins. Mutations in this gene are associated with Wolcott-Rallison syndrome.
