Background：Ly6C is a monocyte/macrophage and endothelial cell differentiation antigen regulated by interferon gamma, and may play a role in the development and maturation of lymphocytes. It is a member of the Ly6 multigene family of type V glycophosphatidylinositol anchored cell surface proteins. It is expressed on bone marrow cells, monocytes/macrophages, neutrophils, endothelial cells, and T cell subsets. Mice with the Ly6.2 allotype （e.g., AKR, C57BL, C57BR, C57L, DBA/2, PL, SJL, SWR, 129） have subsets of CD4+Ly6C+ and CD8+Ly6C+ cells, while Ly6.1 strains （e.g., A, BALB/c, CBA, C3H/He, DBA/1, NZB） have only CD8+Ly6C+ lymphocytes.
