Background：Programmed cell death ligand 1（CD274,or B7-H1,PD-L1）,is the first member of B7 family to be discovered. B7 family molecules are type I transmembrane proteins belonging to the immunoglobulin superfamily. In concert with their CD28 family receptors,the B7s are key regulators of the adaptive immune response. CD274 is suggested a negative regulator of T and B cell,and play important role in mediating tolerance of lymphocytes to self-antigens. It also involved in the costimulatory signal,essential for T-cell proliferation and production of IL10 and IFNG,in an IL2-dependent and a PDCD1-independent manner. PD-L1 is a 290 aa transmembrane protein with a calculated molecular weight of 33 kDa,the apparent molecular weight has been reported as 45-70 kDa,suggesting probable glycosylation .
仕様
Synonyms：B7 H,B7 H1,B7 homolog 1,B7-H1,B7H,B7H1,CD 274,CD274,CD274 antigen,CD274 molecule,MGC142294,MGC142296,OTTHUMP00000021029,PD L1,PD-L1,PD1L1,PDCD1 ligand 1,PDCD1L1,PDCD1LG1,PDL 1,PDL1,Programmed cell death 1 ligand 1,Programmed death ligand 1,RGD1566211
Host：Rabbit
Reactivity：Human,Mouse,Rat
Applications：WB,IHC
Concentration：0.9 mg/mL
Immunogen：KLH conjugated Synthetic peptide corresponding to Mouse PD-L1
Purification Method：Affinity purification
Clonality：Polyclonal
Conjugation：Unconjugated
Buffer：PBS with 0.02％ sodium azide,100 ug/ml BSA and 50％ glycerol.
