Background：PKM2,also named as OIP3,PK2,PK3,PKM,p58,THBP1,CTHBP and Tumor M2-PK,belongs to the pyruvate kinase family. It is glycolytic enzyme that catalyzes the transfer of a phosphoryl group from phosphoenolpyruvate （PEP） to ADP,generating ATP. It stimulates POU5F1-mediated transcriptional activation. PKM2 plays a general role in caspase independent cell death of tumor cells. The activity of the M2 isoform （but not the M1 isoform） can be inhibited by tyrosine kinase signaling in tumourcells.The primary pyruvate kinase isoform before tumour development is PK-M1; however,the primary isoform from four independent tumours is PK-M2. PKM2,Pyruvate kinase isozymes M1/M2,has 2 isoforms .The immunogen of this antibody is M2 isoform,also called PKM2.
仕様
Synonyms：CTHBP,Cytosolic thyroid hormone binding protein,Cytosolic thyroid hormone-binding protein,KPYM,MGC3932,OIP 3,OIP-3,OIP3,OPA interacting protein 3,Opa-interacting protein 3,p58,PK muscle type,PK,muscle type,PK2,PK3,PKM,PKM2,pykm,Pyruvate kinase 2/3,Pyruvate kinase 3,Pyruvate kinase isozymes M1/M2,Pyruvate kinase muscle,Pyruvate kinase muscle isozyme,pyruvate kinase PKM,Pyruvate kinase,muscle 2,TCB,THBP1,Thyroid hormone binding protein 1,Thyroid hormone binding protein cytosolic,Thyroid hormone-binding protein 1,Tumor M2 PK,Tumor M2-PK
Host：Rabbit
Reactivity：Human,Mouse,Rat
Applications：WB
Concentration：440 ug/mL
Immunogen：Recombinant protein corresponding to Mouse PKM2
Purification Method：Affinity purification
Clonality：Polyclonal
Conjugation：Unconjugated
Buffer：PBS with 0.02％ sodium azide,100 ug/ml BSA and 50％ glycerol.
Dilution：WB 1：500-1：1000
Swissprot：P14618,P52480,P11980
Isotype：IgG
Research Areas：Cancer, Epigenetics and Nuclear Signaling, Metabolism, Signal transduction
