Background：This gene encodes the mineralocorticoid receptor, which mediates aldosterone actions on salt and water balance within restricted target cells. The protein functions as a ligand-dependent transcription factor that binds to mineralocorticoid response elements in order to transactivate target genes. Mutations in this gene cause autosomal dominant pseudohypoaldosteronism type I, a disorder characterized by urinary salt wasting. Defects in this gene are also associated with early onset hypertension with severe exacerbation in pregnancy. Alternative splicing results in multiple transcript variants.
仕様
Synonyms：Aldosterone receptor,MCR,MGC133092,Mineralocorticoid receptor,MLR,MR,NR3 C2,NR3C2,NR3C2 protein,Nuclear receptor subfamily 3 group C member 2
Host：Rabbit
Reactivity：Human
Applications：WB
Concentration：1.3 mg/mL
Immunogen：KLH conjugated Synthetic peptide corresponding to Mouse Mineralocorticoid receptor
Purification Method：Affinity purification
Clonality：Polyclonal
Conjugation：Unconjugated
Buffer：PBS with 0.02％ sodium azide,100 ug/ml BSA and 50％ glycerol.
Dilution：WB 1：500-1：1000
Swissprot：P08235
Isotype：IgG
Research Areas：Signal Transduction,Cardiovascular,Epigenetics and Nuclear Signaling
