Background：Peroxisome proliferator-activated receptor alpha （PPARA） is a ligand-activated transcription factor that belongs to the PPAR nuclear receptor superfamily. PPARA is essential in the modulation of lipid transport and metabolism, mainly through activating mitochondrial and peroxisomal fatty acid b-oxidation pathways. In addition, PPARA seems to decrease inflammation mainly through direct interaction with NF-kappaB, causing inhibition of its signaling pathway or reducing the activated levels of NF-kappaB and subsequent inflammation. Furthermore, PPARA was implicated in the attenuation of oxidative stress in alcoholic liver disease when treated with polyenephosphatidylcholine through downregulation of ROS-generating enzymes such as ethanol-inducible cytochrome P450 2E1 （CYP2E1）, acyl-CoA oxidase, and NADPH oxidase.
仕様
Synonyms：hPPAR,MGC2237,MGC2452,NR1C1,Nuclear receptor subfamily 1 group C member 1,OTTHUMP00000197740,OTTHUMP00000197741,Peroxisome proliferative activated receptor alpha,Peroxisome proliferator activated receptor alpha,Peroxisome proliferator-activated receptor alpha,PPAR,PPAR-alpha,ppara,PPARA,PPARalpha
Host：Rabbit
Reactivity：Mouse,Rat
Applications：IHC
Concentration：0.6 mg/mL
Immunogen：KLH conjugated Synthetic peptide corresponding to Mouse PPARa
Purification Method：Affinity purification
Clonality：Polyclonal
Conjugation：Unconjugated
Buffer：PBS with 0.02％ sodium azide,100 ug/ml BSA and 50％ glycerol.
Dilution：IHC 1：200-1：500
Swissprot：P23204,P37230
Isotype：IgG
Research Areas：Cancer, Cardiovascular, Epigenetics and Nuclear Signaling, Metabolism, Signal transduction
