Background：LDLR （low density lipoprotein receptor） is a member of the LDL receptor gene family and is involved in receptor-mediated endocytosis of specific ligands. The LDLR is a cell surface glycoprotein that scavenges LDL from the blood and regulates plasma LDL cholesterol. The cytoplasmic domain of the LDL receptor is necessary for the receptor to cluster in coated pits,which promotes the rapid endocytosis of bound LDL. The protein is highly glycosylated through N- and O-linkages and thus migrates at 100 to 160 kDa bands on SDS-PAGE.
仕様
Synonyms：FH,FHC,LDL R,LDL receptor,LDLCQ2,Ldlr,LDLR,Low Density Lipoprotein Receptor,Low density lipoprotein receptor class A domain containing protein 3,Low density lipoprotein receptor familial hypercholesterolemia,Low-density lipoprotein receptor
Host：Rabbit
Reactivity：Human,Mouse,Rat
Applications：IHC
Concentration：1 mg/mL
Immunogen：KLH conjugated Synthetic peptide corresponding to LDL Receptor
Purification Method：Affinity purification
Clonality：Polyclonal
Conjugation：Unconjugated
Buffer：PBS with 0.02％ sodium azide,100 ug/ml BSA and 50％ glycerol.
Dilution：IHC 1：200-1：1000
Swissprot：P01130,P35951,P35952
Isotype：IgG
Research Areas：Cancer, Cardiovascular, Metabolism, Signal transduction
