Background：This gene encodes the alpha chain of type XVIII collagen. This collagen is one of the multiplexins, extracellular matrix proteins that contain multiple triple-helix domains （collagenous domains） interrupted by non-collagenous domains. The proteolytically produced C-terminal fragment of type XVIII collagen is endostatin, a potent antiangiogenic protein. Mutations in this gene are associated with Knobloch syndrome. The main features of this syndrome involve retinal abnormalities, so type XVIII collagen may play an important role in retinal structure and in neural tube closure. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
仕様
Synonyms：Antiangiogenic agent,COIA1,Col18a1,Collagen alpha 1（XVIII） chain,Collagen type XVIII alpha 1,Endostatin,KNO,KNO1,KS,Multi functional protein MFP
Host：Rabbit
Reactivity：Human,Mouse
Applications：IHC
Concentration：1.1 mg/mL
Immunogen：KLH conjugated Synthetic peptide corresponding to Mouse Endostatin
Purification Method：Affinity purification
Clonality：Polyclonal
Conjugation：Unconjugated
Buffer：PBS with 0.02％ sodium azide,100 ug/ml BSA and 50％ glycerol.
Dilution：IHC 1：500-1：1500
Swissprot：P39060,P39061
Isotype：IgG
Research Areas：Cancer, Cardiovascular, Signal transduction
