Background：This gene encodes a member of the doublecortin family. The protein encoded by this gene is a cytoplasmic protein and contains two doublecortin domains, which bind microtubules. In the developing cortex, cortical neurons must migrate over long distances to reach the site of their final differentiation. The encoded protein appears to direct neuronal migration by regulating the organization and stability of microtubules. In addition, the encoded protein interacts with LIS1, the regulatory gamma subunit of platelet activating factor acetylhydrolase, and this interaction is important to proper microtubule function in the developing cortex. Mutations in this gene cause abnormal migration of neurons during development and disrupt the layering of the cortex, leading to epilepsy, cognitive disability, subcortical band heterotopia （"double cortex" syndrome） in females and lissencephaly （"smooth brain" syndrome） in males. Multiple transcript variants encoding different isoforms have been found for this gene.
仕様
Synonyms：DBCN,Dbct,DC,DCX,DCX,Doublecortex,Doublin,FLJ51296,Lis X,Lis-X,Lissencephalin X,Lissencephalin-X,Lissencephaly X linked,Lissencephaly X linked doublecortin,LISX,Neuronal migration protein doublecortin,OTTHUMP00000023859,OTTHUMP00000023860,OTTHUMP00000216315,OTTHUMP00000216316,SCLH,XLIS
Host：Rabbit
Reactivity：Mouse,Rat
Applications：IHC
Concentration：0.93 mg/mL
Immunogen：KLH conjugated Synthetic peptide corresponding to Mouse DCX
Purification Method：Affinity purification
Clonality：Polyclonal
Conjugation：Unconjugated
Buffer：PBS with 0.02％ sodium azide,100 ug/ml BSA and 50％ glycerol.
Dilution：IHC 1：1000-1：2000
Swissprot：O88809,Q9ESI7
Isotype：IgG
Research Areas：Cancer, Neuroscience, Tags ＆ Cell Markers
