Background：The TEK receptor tyrosine kinase is expressed almost exclusively in endothelial cells in mice, rats, and humans. This receptor possesses a unique extracellular domain containing 2 immunoglobulin-like loops separated by 3 epidermal growth factor-like repeats that are connected to 3 fibronectin type III-like repeats. The ligand for the receptor is angiopoietin-1. Defects in TEK are associated with inherited venous malformations; the TEK signaling pathway appears to be critical for endothelial cell-smooth muscle cell communication in venous morphogenesis. TEK is closely related to the TIE receptor tyrosine kinase.
仕様
Synonyms：Angiopoietin 1 receptor,Angiopoietin-1 receptor,CD202b,CD202b antigen,Endothelial tyrosine kinase,Endothelium specific receptor tyrosine kinase 2,hTIE 2,hTIE2,Hyk,p140 TEK,Soluble TIE2 variant 1,Soluble TIE2 variant 2,Tek,tek tyrosine kinase,TEK tyrosine kinase endothelial,tek tyrosine kinase,endothelial,TIE 2,TIE2,TIE2,Tunica interna endothelial cell kinase,Tyrosine kinase with Ig and EGF homology domains 2,Tyrosine kinase with Ig and EGF homology domains-2,Tyrosine protein kinase receptor TEK,Tyrosine protein kinase receptor TIE 2,Tyrosine-protein kinase receptor TEK,Tyrosine-protein kinase receptor TIE-2,Venous malformations multiple cutaneous and mucosal,VMCM 1,VMCM,VMCM1
Host：Rabbit
Reactivity：Human,Mouse,Rat
Applications：IHC
Concentration：470 ug/mL
Immunogen：KLH conjugated Synthetic peptide corresponding to Mouse Tie2
Purification Method：Affinity purification
Clonality：Polyclonal
Conjugation：Unconjugated
Buffer：PBS with 0.02％ sodium azide,100 ug/ml BSA and 50％ glycerol.
Dilution：IHC 1：200-1：800
Swissprot：Q02763,Q02858
Isotype：IgG
Research Areas：Cancer, Cardiovascular, Developmental biology, Signal transduction, Stem cells
