Background：This gene encodes a pyrin-like protein containing a pyrin domain, a nucleotide-binding site （NBS） domain, and a leucine-rich repeat （LRR） motif. This protein interacts with the apoptosis-associated speck-like protein PYCARD/ASC, which contains a caspase recruitment domain, and is a member of the NALP3 inflammasome complex. This complex functions as an upstream activator of NF-kappaB signaling, and it plays a role in the regulation of inflammation, the immune response, and apoptosis. Mutations in this gene are associated with familial cold autoinflammatory syndrome （FCAS）, Muckle-Wells syndrome （MWS）, chronic infantile neurological cutaneous and articular （CINCA） syndrome, and neonatal-onset multisystem inflammatory disease （NOMID）. Multiple alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene. Alternative 5' UTR structures are suggested by available data; however, insufficient evidence is available to determine if all of the represented 5' UTR splice patterns are biologically valid.
仕様
Synonyms：AGTAVPRL,AII/AVP,Angiotensin/vasopressin receptor AII/AVP like,Angiotensin/vasopressin receptor AII/AVP-like,C1orf7,Caterpiller protein 1.1,CIAS 1,CIAS1,CLR1.1,Cold autoinflammatory syndrome 1,Cold autoinflammatory syndrome 1 protein,Cryopyrin,Familial cold autoinflammatory syndrome,FCAS,FCU,LRR and PYD domains-containing protein 3,Muckle-Wells syndrome,MWS,NACHT,NACHT LRR and PYD containing protein 3,NALP 3,NALP3,NALP3,NLR family pyrin domain containing 3,NLRP3,PYPAF 1,PYPAF1,PYRIN containing APAF1 like protein 1,PYRIN-containing APAF1-like protein 1
Host：Rabbit
Reactivity：Human,Mouse
Applications：IHC
Concentration：0.65 mg/mL
Immunogen：KLH conjugated Synthetic peptide corresponding to Mouse NLRP3
Purification Method：Affinity purification
Clonality：Polyclonal
Conjugation：Unconjugated
Buffer：PBS with 0.02％ sodium azide,100 ug/ml BSA and 50％ glycerol.
Dilution：IHC 1：600-1：1200
Swissprot：Q96P20,Q8R4B8
Isotype：IgG
Research Areas：Cancer, Cell Biology, Cardiovascular, Immunology, Signal transduction
