Background：FOXO1,also named as FOXO1A,FKHR and FKH1,is a member of the FOXO subfamily of Forkhead transcription factors. FOXO1 is a transcription factor which acts as a regulator of cell responses to oxidative stress. FOXO1 interacts with LRPPRC and SIRT1. In the presence of KIRT1,FOXO1 mediates down-regulation of cyclin D1 and up-regulation of CDKN1B levels which are required for cell transition from proliferative growth to quiescence. FOXO1 contains three predicted protein kinase B phosphorylation sites （Thr-24,Ser-256,and Ser-319） that are conserved in other FOXO proteins. The t（2;13） and the variant t（1;13） translocations generate PAX3/FKHR and PAX7/FKHR fusion proteins respectively. The resulting protein is a transcriptional activator. Defects in FOXO1 are a cause of rhabdomyosarcoma type 2 （RMS2）.
仕様
Synonyms：FKH 1,FKH1,FKHR,Forkhead （Drosophila） homolog 1 （rhabdomyosarcoma）,Forkhead box O1,Forkhead box protein O1,Forkhead box protein O1A,Forkhead in rhabdomyosarcoma,Forkhead,Drosophila,homolog of,in rhabdomyosarcoma,FoxO transcription factor,foxo1,FOXO1,FOXO1A,OTTHUMP00000018301
Host：Rabbit
Reactivity：Human,Mouse,Rat
Applications：IHC
Concentration：320 ug/mL
Immunogen：Recombinant protein corresponding to Mouse FOXO1
Purification Method：Affinity purification
Clonality：Polyclonal
Conjugation：Unconjugated
Buffer：PBS with 0.02％ sodium azide,100 ug/ml BSA and 50％ glycerol.
Dilution：IHC 1：800-1：1600
Swissprot：Q12778,Q9R1E0,G3V7R4
Isotype：IgG
Research Areas：Cancer, Epigenetics and Nuclear Signaling, Metabolism, Neuroscience, Signal transduction
