Background：PGR,also named as NR3C3 and PR,belongs to the nuclear hormone receptor family and NR3 subfamily. The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Progesterone receptor isoform B （PRB） is involved activation of c-SRC/MAPK signaling on hormone stimulation. The ER and PR status has been used as a predictor of breast carcinoma responsiveness to endocrine therapy and as a prognostic indicator for early recurrence.
仕様
Synonyms：NR3C3,Nuclear receptor subfamily 3 group C member 3,PGR,PR,PRA,PRB,PRGR,Progesterone receptor,Progestin receptor form A,Progestin receptor form B
Host：Rabbit
Reactivity：Human,Mouse
Applications：IHC
Concentration：1.32 mg/mL
Immunogen：KLH conjugated Synthetic peptide corresponding to Mouse Progesterone receptor
Purification Method：Affinity purification
Clonality：Polyclonal
Conjugation：Unconjugated
Buffer：PBS with 0.02％ sodium azide,100 ug/ml BSA and 50％ glycerol.
Dilution：IHC 1：500-1：1000
Swissprot：P06401,Q00175,Q63449
Isotype：IgG
Research Areas：Cancer, Epigenetics and Nuclear Signaling, Neuroscience, Signal transduction
