Background：The androgen receptor gene is more than 90 kb long and codes for a protein that has 3 major functional domains： the N-terminal domain, DNA-binding domain, and androgen-binding domain. The protein functions as a steroid-hormone activated transcription factor. Upon binding the hormone ligand, the receptor dissociates from accessory proteins, translocates into the nucleus, dimerizes, and then stimulates transcription of androgen responsive genes. This gene contains 2 polymorphic trinucleotide repeat segments that encode polyglutamine and polyglycine tracts in the N-terminal transactivation domain of its protein.
仕様
Synonyms：AIS,ANDR,Androgen nuclear receptor variant 2,Androgen receptor （dihydrotestosterone receptor,testicular feminization,spinal and bulbar muscular atrophy,Kennedy disease）,Androgen receptor,androgen receptor splice variant 4b,AR,AR8,DHTR,Dihydro testosterone receptor,Dihydrotestosterone receptor （DHTR）,Dihydrotestosterone receptor,HUMARA,HYSP1,KD,Kennedy disease （KD）,NR3C4,Nuclear receptor subfamily 3 group C member 4 （NR3C4）,Nuclear receptor subfamily 3 group C member 4,SBMA,SMAX1,Spinal and bulbar muscular atrophy （SBMA）,Spinal and bulbar muscular atrophy,Testicular Feminization （TFM）,TFM
Host：Rabbit
Reactivity：Human,Mouse,Rat
Applications：IHC
Concentration：0.83 mg/mL
Immunogen：KLH conjugated Synthetic peptide corresponding to Mouse Androgen receptor
Purification Method：Affinity purification
Clonality：Polyclonal
Conjugation：Unconjugated
Buffer：PBS with 0.02％ sodium azide,100 ug/ml BSA and 50％ glycerol.
Dilution：IHC 1：500-1：1000
Swissprot：P10275;P19091;P15207
Isotype：IgG
Research Areas：Cancer, Epigenetics and Nuclear Signaling, Developmental biology, Signal transduction
