Background：Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor,alpha （NFKBIA,synonyms： IKBA,MAD-3,NFKBI）. NFKB1 or NFKB2 is bound to REL,RELA ,or RELB to form the NFKB complex. The NFKB complex is inhibited by I-kappa-B proteins （NFKBIA or NFKBIB）,which inactivate NF-kappa-B by trapping it in the cytoplasm. Phosphorylation of serine residues on the I-kappa-B proteins by kinases （IKBKA,or IKBKB） marks them for destruction via the ubiquitination pathway,thereby allowing activation of the NF-kappa-B complex. Activated NFKB complex translocates into the nucleus and binds DNA at kappa-B-binding motifs such as 5-prime GGGRNNYYCC 3-prime or 5-prime HGGARNYYCC 3-prime.
仕様
Synonyms：I kappa B alpha,I-kappa-B-alpha,IkappaBalpha,IkB-alpha,IKBA,IKBA,IKBalpha,MAD 3,MAD3,Major histocompatibility complex enhancer-binding protein MAD3,NF kappa B inhibitor alpha,NF-kappa-B inhibitor alpha,NFKBI,NFKBIA,Nuclear factor of kappa light chain gene enhancer in B cells,Nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor alpha
Host：Rabbit
Reactivity：Human
Applications：IHC
Concentration：1.3 mg/mL
Immunogen：KLH conjugated Synthetic peptide corresponding to Mouse IKBa
Purification Method：Affinity purification
Clonality：Polyclonal
Conjugation：Unconjugated
Buffer：PBS with 0.02％ sodium azide,100 ug/ml BSA and 50％ glycerol.
Dilution：IHC 1：500-1：1000
Swissprot：P25963,Q9Z1E3
Isotype：IgG
Research Areas：Cancer, Epigenetics and Nuclear Signaling, Immunology, Signal transduction
