Background：Vimentin,also named as VIM,belongs to the intermediate filament family. Vimentin is class-III intermediate filaments found in various non-epithelial cells,especially mesenchymal cells. Vimentin is important for stabilizing the architecture of the cytoplasm. Monocyte-derived macrophages secrete vimentin into the extracellular space in vitro. Secretion of vimentin was enhanced by the proinflammatory cytokine tumor necrosis factor-alpha （TNFA; 191160） and inhibited by the antiinflammatory cytokine IL10 （124092）,suggesting that vimentin is involved in the immune response. Vimentin has specialized functions that contribute to specific dynamic cellular processes. As a phosphoprotein,55-60 kDa of vimentin proteins can be observed due to the different phosphorylation level.
仕様
Synonyms：CTRCT30,Epididymis luminal protein 113,FLJ36605,HEL113,VIM,VIME,Vimentin
Host：Rabbit
Reactivity：Human,Mouse,Rat
Applications：WB,IHC
Concentration：1.1 mg/mL
Immunogen：KLH conjugated Synthetic peptide corresponding to Mouse vimentin
Purification Method：Affinity purification
Clonality：Polyclonal
Conjugation：Unconjugated
Buffer：PBS with 0.02％ sodium azide,100 ug/ml BSA and 50％ glycerol.
Dilution：WB 1：1000, IHC 1：500-1：1000
Swissprot：P08670,P20152,P31000
Isotype：IgG
Research Areas：Cancer, Developmental biology, Neuroscience, Signal transduction, Stem cells
