Background：IL17A,also named as IL-17,is a proinflammatory cytokine. IL-17,synthesized only by memory T cells and natural killer cells,has pleiotropic effects,mainly in the recruitment and activation of neutrophils. This cytokine regulates the activities of NF-kappaB and mitogen-activated protein kinases. This cytokine can stimulate the expression of IL6 and cyclooxygenase-2 （PTGS2/COX-2）,as well as enhance the production of nitric oxide （NO）. High levels of this cytokine are associated with several chronic inflammatory diseases including rheumatoid arthritis,psoriasis and multiple sclerosis. The IL-17 receptor is a type I transmembrane protein,that is widely expressed on epithelial cells,fibroblasts,B and T cells,and monocytic cells. In psoriatic skin lesions,both Th17 cells and their downstream effector molecules,e.g. IL-17 and IL-22,are highly increased.
仕様
Synonyms：CTLA 8,CTLA-8,CTLA8,Cytotoxic T lymphocyte associated antigen 8,Cytotoxic T lymphocyte associated protein 8,Cytotoxic T lymphocyte associated serine esterase 8,Cytotoxic T-lymphocyte-associated antigen 8,IL 17A,IL-17,IL-17A,IL17,IL17,Il17a,Interleukin 17 （cytotoxic T lymphocyte associated serine esterase 8）,Interleukin 17A,Interleukin-17A,Interleukin17,Interleukin17A,OTTHUMP00000016597,OTTMUSP00000046003
Host：Rabbit
Reactivity：Mouse,Rat
Applications：IHC
Concentration：360 ug/mL
Immunogen：KLH conjugated Synthetic peptide corresponding to Mouse IL-17A
Purification Method：Affinity purification
Clonality：Polyclonal
Conjugation：Unconjugated
Buffer：PBS with 0.02％ sodium azide,100 ug/ml BSA and 50％ glycerol.
