Background：Eukaryotic translation initiation factor 4E-binding protein 1（4EBP1）,is a member of 4EBPs family,which regulate the translation of a subset of mRNA by competing with eIF4G for binding to eIF4E,thus preventing the assembly of the eIF4F complex. The eIF4F facilitates the recruitment of other translation initiation factors to form the complex and then initiates cap-dependent translation.4EBP1 also mediates the regulation of protein translation by growth factors,hormones and other stimuli that signal through the MAP kinase and mTORC1 pathways. There are three forms of 4EBP1,alpha,beta and gamma.
仕様
Synonyms：4E-BP1,4EBP1,4EBP1,BP 1,eIF4E binding protein 1,eIF4E-binding protein 1,Eif4ebp1,Eukaryotic translation initiation factor 4E-binding protein 1,PHAS-I,PHASI,Phosphorylated heat- and acid-stable protein regulated by insulin 1
Host：Rabbit
Reactivity：Human
Applications：IHC
Concentration：2mg/mL
Immunogen：Recombinant Human Eukaryotic translation initiation factor 4E-binding protein 1 protein
Purification Method：Affinity purification
Clonality：Polyclonal
Conjugation：Unconjugated
Buffer：PBS with 0.05％ Proclin300, 50％ glycerol, pH7.3.
Dilution：IHC 1：100-1：400
Gene_ID（human）：1978
Swissprot：Q13541
Isotype：IgG
Research Areas：Cancer, Epigenetics and Nuclear Signaling, Metabolism
