Background：PTEN （also designated MMAC1）,products of tumor suppressor genes,are found deleted in most human gliomas. The PTEN genes are also mutated in many other tumors,such as brain,breast,kidney and prostate cancers. PTEN is a protein tyrosine phosphatase that may terminate the signaling transduction pathways mediated by PI 3-kinase/Akt. PTEN has an apparent molecular weight of 55 kDa and it is located in the cytosol.
仕様
Synonyms：10q23del,BZS,DEC,GLM2,MGC11227,MHAM,MMAC1,MMAC1 phosphatase and tensin homolog deleted on chromosome 10,Mutated in multiple advanced cancers 1,Phosphatase and tensin homolog,Phosphatase and tensin like protein,Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN,Pten,PTEN,PTEN1,TEP1
Host：Rabbit
Reactivity：Human,Mouse
Applications：WB,IHC,IF
Concentration：0.89mg/mL
Immunogen：Recombinant Human Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN protein
Purification Method：Antigen Affinity Purification
Clonality：Polyclonal
Buffer：PBS with 0.05％ Proclin300, 50％ glycerol, pH7.3.
Dilution：WB 1：500-1：1000 IHC 1：100-1：200 IF 1：100-1：400
Gene_ID（human）：5728
Swissprot：P60484
Isotype：IgG
Research Areas：Cancer, Cell Biology, Epigenetics and Nuclear Signaling, Metabolism, Signal Transduction
