Background：Hexokinases phosphorylate glucose to produce glucose-6-phosphate, the first step in most glucose metabolism pathways. Alternative splicing of this gene results in three tissue-specific forms of glucokinase, one found in pancreatic islet beta cells and two found in liver. The protein localizes to the outer membrane of mitochondria. In contrast to other forms of hexokinase, this enzyme is not inhibited by its product glucose-6-phosphate but remains active while glucose is abundant. Mutations in this gene have been associated with non-insulin dependent diabetes mellitus （NIDDM）, maturity onset diabetes of the young, type 2 （MODY2） and persistent hyperinsulinemic hypoglycemia of infancy （PHHI）.
仕様
Synonyms：ATP：D-hexose 6-phosphotransferase,FGQTL3,GCK,GK,GLK,Glucokinase,Hexokinase D pancreatic isozyme,Hexokinase type IV,Hexokinase-4,Hexokinase-D,HHF3,HK IV,HK4,HKIV,HXK4,HXKP,LGLK,MODY2
Host：Rabbit
Reactivity：Human,Mouse
Applications：WB,IHC,IF
Concentration：1mg/mL
Immunogen：Recombinant Mouse Glucokinase protein
Purification Method：Antigen Affinity Purification
Clonality：Polyclonal
Buffer：PBS with 0.05％ Proclin300, 50％ glycerol, pH7.3.
Dilution：WB 1：1000-1：2000 IHC 1：100-1：200 IF 1：100-1：400
Gene_ID（human）：103988
Swissprot：P52792
Isotype：IgG
Research Areas：Cancer, Metabolism, Signal Transduction
