Background：IFITM3,also named as interferon-inducible protein 1-8U,belongs to the CD225 family. It is IFN-induced antiviral protein that mediates cellular innate immunity to at least three major human pathogens,namely influenza A H1N1 virus,West Nile virus （WNV）,and dengue virus,by inhibiting the early steps of replication. IFITM3 is identified as interferon-induced cellular proteins that restrict infections by retroviruses and filoviruses and of influenza virus and flaviviruses,respectively. IFITM3,the most potent antiviral IFITM,was found to inhibit an uncharacterized early infectious event after VSV endocytosis,but before primary transcription of its viral genome. IFITM proteins are viral restriction factors that can inhibit infection mediated by the influenza A virus （IAV） hemagglutinin （HA） protein. They differentially restrict the entry of a broad range of enveloped viruses,and modulate cellular tropism independently of viral receptor expression. This antibody recognizes both IFITM2 and IFITM3.
仕様
Synonyms：1 8U,Fragilis,IFITM3,IFM3,Interferon induced transmembrane protein 3 （1 8U）,Interferon Induced Transmembrane Protein 3,Interferon inducible,Interferon inducible protein 1 8U,Interferon Inducible Protein 15,Interferon Inducible Protein Homolog,Interferon-induced transmembrane protein 3,Interferon-inducible protein 1-8U,IP15
Host：Rabbit
Reactivity：Human,Mouse,Rat
Applications：WB,IHC,IF
Concentration：1mg/mL
Immunogen：Recombinant Rat Interferon-induced transmembrane protein 3 protein
Purification Method：Antigen Affinity Purification
Clonality：Polyclonal
Buffer：PBS with 0.05％ Proclin300, 50％ glycerol, pH7.3.
Dilution：WB 1：1000-1：2000 IHC 1：50-1：200 IF 1：100-1：400
Gene_ID（human）：361673
Swissprot：P26376
Isotype：IgG
Research Areas：Cancer, Developmental Biology, Stem Cells
