Background：Machado-Joseph disease, also known as spinocerebellar ataxia-3, is an autosomal dominant neurologic disorder. The protein encoded by this gene contains （CAG）n repeats in the coding region, and the expansion of these repeats from the normal 12-44 to 52-86 is one cause of Machado-Joseph disease. There is a negative correlation between the age of onset and CAG repeat numbers. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.
仕様
Synonyms：AT3,Ataxin 3,ataxin 3 variant h,ataxin 3 variant m,ataxin 3 variant ref,Ataxin-3,ATX3,EC 3.4.22,JOS,Machado Joseph disease,MJD,Olivopontocerebellar ataxia 3,OTTHUMP00000221583,Rsca3,Spinocerebellar ataxia type 3 protein
Host：Rabbit
Reactivity：Human,Mouse,Rat
Applications：WB,IHC
Concentration：2mg/mL
Immunogen：Recombinant Human Ataxin-3 protien
Purification Method：Affinity purification
Clonality：Polyclonal
Conjugation：Unconjugated
Dilution：WB 1：500-1：2000 IHC 1：50-1：200
Gene_ID（human）：4287
Swissprot：P54252
Isotype：IgG
Research Areas：Cancer, Epigenetics and Nuclear Signaling, Neuroscience
