Background：The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is activated by various cell stimuli, and targets specific transcription factors, and thus mediates immediate-early gene expression in response to cell stimuli. The activation of this kinase by tumor-necrosis factor alpha （TNF-alpha） is found to be required for TNF-alpha induced apoptosis. This kinase is also involved in UV radiation induced apoptosis, which is thought to be related to cytochrom c-mediated cell death pathway. Studies of the mouse counterpart of this gene suggested that this kinase play a key role in T cell proliferation, apoptosis and differentiation. Several alternatively spliced transcript variants encoding distinct isoforms have been reported.
仕様
Synonyms：C Jun kinase 2,c Jun N terminal kinase 1,c Jun N terminal kinase 2,c Jun N terminal kinase 3,c-Jun N-terminal kinase 1,JNK 46,JNK 55,JNK,JNK-46,JNK1,JNK1A2,JNK2,JNK21B1/2,JNK2A,JNK2ALPHA,JNK2B,JNK2BETA,JNK3 alpha protein kinase,JNK3,JNK3A,Jun kinase,JUN N terminal kinase,MAP kinase 10,MAP kinase 8,MAP kinase 9,MAP kinase p49 3F12,MAPK 10,MAPK 8,MAPK 9,MAPK10,mapk8,MAPK9,Mitogen activated protein kinase 10,Mitogen activated protein kinase 8,Mitogen activated protein kinase 8 isoform JNK1 alpha1,Mitogen activated protein kinase 8 isoform JNK1 beta2,Mitogen activated protein kinase 9,Mitogen-activated protein kinase 8,MK08_HUMAN,p493F12,p54a,p54aSAPK,p54bSAPK,PRKM10,PRKM8,PRKM9,SAPK,SAPK（beta）,SAPK1,SAPK1a,SAPK1b,SAPK1c,Stress activated protein kinase 1,Stress activated protein kinase 1a,Stress activated protein kinase 1b,Stress activated protein kinase 1c,Stress activated protein kinase beta,Stress activated protein kinase JNK1,Stress activated protein kinase JNK2,Stress activated protein kinase JNK3,tress-activated protein kinase 1c,Stress-activated protein kinase JNK1
Host：Rabbit
Reactivity：Rat
Applications：IHC
Concentration：2mg/mL
Immunogen：Recombinant Rat Mitogen-activated protein kinase 8 protien
Purification Method：Affinity purification
Clonality：Polyclonal
Conjugation：Unconjugated
Dilution：IHC 1：50-1：200
Gene_ID（human）：116554
Swissprot：P49185
Isotype：IgG
Research Areas：Signal Transduction,Cancer,Immunology
