Background：KRAS,also called p21,is a member of the Ras superfamily of proteins. It is located on human chromosome 12,and contains four coding exons and a 5' non-coding exon （PMID： 12778136）. KRAS is a membrane-anchored guanosine triphosphate/guanosine diphosphate （GTP/GDP）-binding protein and is widely expressed in most human cells. Like other members of the Ras family,the KRAS protein is a GTPase,and it is involved in intracellular signal transduction and mainly responsible for EGFR-signaling activation （PMID： 19117687）. KRAS mutations have been found in various malignancies,including lung adenocarcinoma,mucinous adenoma,ductal carcinoma of the pancreas and colorectal carcinoma. KRAS has two isoforms,a and b.
仕様
Synonyms：c Ki ras2,c Kirsten ras protein,c-K-ras,c-Ki-ras,Cellular c Ki ras2 proto oncogene,Cellular transforming proto oncogene,CFC2,cK Ras,GTPase KRas,K RAS p21 protein,K RAS2A,K RAS2B,K RAS4A,K RAS4B,K-Ras 2,KI RAS,Ki-Ras,KIRSTEN MURINE SARCOMA VIRUS 2,Kirsten rat sarcoma 2 viral （v Ki ras2） oncogene homolog,Kirsten rat sarcoma viral oncogene homolog,KRAS,KRAS proto oncogene,GTPase,KRAS1,KRAS2,N-terminally processed,NS,NS3,Oncogene KRAS2,p21ras,PR310 c K ras oncogene,PR310 cK ras oncogene,RALD,RASK,RASK2,Transforming protein p21,v Ki ras2 Kirsten rat sarcoma 2 viral oncogene homolog,v Ki ras2 Kirsten rat sarcoma viral oncogene homolog
Host：Rabbit
Reactivity：Human,Mouse
Applications：WB
Concentration：2mg/mL
Immunogen：Recombinant Human GTPase KRas protein
Purification Method：Affinity purification
Clonality：Polyclonal
Conjugation：Unconjugated
Dilution：WB 1：500-1：2000
Gene_ID（human）：3845
Swissprot：P01116
Isotype：IgG
Research Areas：Cancer, Epigenetics and Nuclear Signaling, Signal transduction
