Background：Alkylating agents are potent carcinogens that can result in cell death, mutation and cancer. The protein encoded by this gene is a DNA repair protein that is involved in cellular defense against mutagenesis and toxicity from alkylating agents. The protein catalyzes transfer of methyl groups from O（6）-alkylguanine and other methylated moieties of the DNA to its own molecule, which repairs the toxic lesions. Methylation of the genes promoter has been associated with several cancer types, including colorectal cancer, lung cancer, lymphoma and glioblastoma.
仕様
Synonyms：6 O methylguanine DNA methyltransferase,6-O-methylguanine-DNA methyltransferase,Agat,AGT,AI267024,EC 2.1.1.63,Methylated DNA protein cysteine methyltransferase,Methylated-DNA--protein-cysteine methyltransferase,Methylguanine DNA methyltransferase,MGC107020,MGMT,MGMT,O 6 methylguanine DNA alkyltransferase,O 6 methylguanine DNA methyltransferase,O-6-methylguanine-DNA methyltransferase,O-6-methylguanine-DNA-alkyltransferase
Host：Rabbit
Reactivity：Human
Applications：WB
Concentration：2mg/mL
Immunogen：Recombinant human Methylated DNA protein cysteine methyltransferase protein
Purification Method：Affinity purification
Clonality：Polyclonal
Conjugation：Unconjugated
Buffer：PBS with 0.05％ Proclin300, 50％ glycerol, pH7.3.
Dilution：WB 1：500-1：1000
Gene_ID（human）：4255
Swissprot：P16455
Isotype：IgG
Research Areas：Cancer, Epigenetics and Nuclear Signaling
