Background：May be involved in p53/TP53 mediated inhibition of cellular proliferation in response to DNA damage. Binds to and inhibits cyclin-dependent kinase activity, preventing phosphorylation of critical cyclin-dependent kinase substrates and blocking cell cycle progression. Functions in the nuclear localization and assembly of cyclin D-CDK4 complex and promotes its kinase activity towards RB1. At higher stoichiometric ratios, inhibits the kinase activity of the cyclin D-CDK4 complex. Inhibits DNA synthesis by DNA polymerase delta by competing with POLD3 for PCNA binding （PubMed：11595739）.
仕様
Synonyms：CDKI,CDKN1A-interacting zinc finger protein 1,Cip1-interacting zinc finger protein,CIZ1,CIZ1,cyclin dependent inhibitor 1A,LSFR1,Melanoma differentiation-associated protein,NP94,Nuclear protein NP94,OPHN3,P21,Zinc finger protein 356,ZNF356
Host：Rabbit
Reactivity：Human
Applications：WB
Concentration：2mg/mL
Immunogen：Recombinant Human P21 protein
Purification Method：Affinity purification
Clonality：Polyclonal
Conjugation：Unconjugated
Buffer：PBS with 0.05％ Proclin300, 50％ glycerol, pH7.3.
Dilution：WB 1：500-1：1000
Gene_ID（human）：1026
Swissprot：P38936
Isotype：IgG
Research Areas：Cell biology, Epigenetics and Nuclear Signaling, Signal transduction
